Skeletal muscle tissue clinical application

Other tissues The effects of these drugs on the heart are discussed in Chapter 14 (see class I antianhythmic agents). Most local anesthetics also have weak blocking effects on skeletal muscle neuromuscular transmission, but these actions have no clinical application. The mood elevation induced by cocaine probably reflects actions on dopamine or other amine-mediated synaptic transmission in the CNS rather than a local anesthetic action on membranes. 

In this chapter we discuss several clinical applications of P NMR. The main emphasis is placed on advances in skeletal muscle (since the review of Glonek et al., 1981), but advances in heart, kidney, brain, eye, and mammalian fluids are also covered. The resonances we deal with are from the phosphorus compounds soluble in the cytoplasm. At the time of this writing, the phospholipids in the membranes of intact tissues are not amenable for P-NMR analysis under the high-resolution conditions cus-... 

---