Six-lead ECG measurement in the conscious dog

1 Six-lead ECG measurement in the conscious dog Conscious studies using integrated telemetry systems devices for measurement of blood pressure and six chest lead ECG measurements (V2, V4, V6, VIO, rV2, and rV4) can be routinely performed. ECG interval analysis is performed on the V2 lead (RR, PR, QT, QTc intervals, QRS duration). QT dispersion can also be measured. Locomotor activity can be monitored and behavior captured on video using CCTV. 

In addition to validated systems for automatic measurement of ECG parameters, ECGs can be reviewed by veterinary cardiology services to detect any transparent abnormalities. 

Respiration rate measurements can be taken from dogs in slings using a pneumograph system. 

An animal-specific correction of QT interval can also be derived for each dog or primate based on individual variability of QT interval with rate using the Framingham equation. 

Studies to assess the effects of compound and any known metabolites on ECG and cardiac action potentials are recommended. Changes in action potential duration and other parameters measured are a functional consequence of effects on the ion channels, which contribute to the action potential. This in vitro test is considered to provide a reliable risk assessment of the potential for a compound to prolong QT interval in man. 

---