SITS 4-acetamido-4 -isothiocyanostilbene 2,2 -disulfonic acid

At least two groups have tested the effects of blockade of the anion channel on the production of O by PMNs Gennaro and Romeo found that the production of O by bovine PMNs was reduced by the blockers of the anion channels SITS (4-acetamido-4 -isothiocyanostilbene-2,2 -disulfonic acid) and ANS (anilino naphthalene disulfonic acid). The consumption of Oj was unaffected. In accord with the expectation if the effects of these agents were to block the anion channel, replace-... 

Fig. 6 Representative trace showing effects of diphenylamine-2-carboxylate (DPC), 4-acetamido-4 -isothiocyanostilbene-2,2 -disulfonic acid (SITS), and bafilomycin on rate of proton secretion. Addition of 0.5 mM DPC had no effect, and 1 mM SITS strongly inhibited...

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