Site saturation

Hydrocracking is a bifunctional process requiring metal as well as acid sites. Saturated reactants are dehydrogenated (Ktjeh,p, o,) on the metal sites yielding dehydrogenated species... 

DeSantis, G., Wong, K., Farwell, B. et al. (2003) Creation of a productive, highly enantioselective nitrilase through gene site saturation mutagenesis (GSSM). Journal of the American Chemical Society, 125, 11476-11477. 

Fig. 21.6 Establishing ligand binding with a cross-saturation experiment. A Chemical structure of NMNH. B Reference spectrum (blue) and binding site-saturated spectrum (red) of NMNH (500 pM) in the presence of [MITJ-DHPR at 2.5 pM...

Parikh, M.R. and Matyoumara, I., Site-saturation mutagenesis is more efficient than DNA shuffling for the directed evolution of / -fucosidase. J. Mol Biol, 2005, 352, 621-628. 

CASTing combinatorial active site saturation test... 

Remember that Y is the fraction of total binding sites saturated. The number of moles of X bound per mole of P is nY and is obtained by summing the concentra-... 

For k+ sites Ak tends to become independent of field above 104 Oe. On k sites saturation occurs at below 102 Oe. 

Gene Site Saturation Mutagenesis (GSSM) All single amino acid substitutions explored. Technically out of reach for most researchers. US Patent 6171820... 

In the present symposium, Dr. Raucher argued that the observed curvature in gas sorption isotherms does not arise from a site saturation mechanism such as we have described in the preceding discussion. The form of the sorption isotherm and local concentration dependent diffusion coefficient proposed by Raucher and Sefcik are given below ... 

Eq (A-l)], but at the same time makes it easier for the penetrant to move through the matrix [Eq (A-2)]. The dual mode model offers the physical interpretation that concavity in the isotherm arises from a site saturation mechanism related to filling of unrelaxed gaps—a phenomenon which is not only easily visualized and understood, but also has been tested explicitly with independently obtained dilatometric data (See Figure 5). 

Site saturation kinetics can also be described with a kinetic model of the form ... 

The two most important nucleation processes are continuous nucleation, that is, when the nucleation rate is temperature dependent according to an Arrhenius equation, and the site saturation process, that is, when all nuclei are present before the growth starts. The two growth processes normally considered are volume diffusion controlled and interface controlled. Finally, the process that interferes with growth is the hard impingement of homogeneously dispersed growing particles. 

---