Sirtuin small molecule inhibitor

Gray SG, Ekstrom TJ (2001) The human histone deacetylase family. Exp Cell Res 262 75—83 Greiner D, Bonaldi T, Eskeland R, Roemer E, Imhof A (2005) Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9. Nat Chem BioH 143-145 Grozinger CM, Chao ED, Blackwell HE, Moazed D, Schreiber SL (2001) Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening. J Biol Chem 276(42) 38837-38843... 

S. L. Schreiber, Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening,... 

Although the Y3H studies reported by our laboratory have focused on the use of kinase inhibitors, a growing number of studies indicate that Y3H is equally suitable for use with other types of small molecules. For example, we have detected bona fide interactions of small molecules with phosphodiesterases (PDEs), histone deacetylases (HDACs), sirtuins (SIRTs), carbonic anhydrase, and various other proteins (manuscript in preparation). 

---