Sinistrin clearance

Buclin T, Pechere-Bertschi A, Saechaud R, et al. Sinistrin clearance for determination of glomerular filtration rate A reappraisal of various approaches using a new analytical method. J Clin Pharmacol 1997 37 679-692. 

ZdUner FG, Schock-Kusch D, Backer S, Neudecker S, Gretz N, and LR Schad (2013). Simultaneous measurement of kidney function by dynamic contrast enhanced MRI and FTTC-sinistrin clearance in rats at 3 tesla initial results. PLoS ONE 8(11) e79992. 

Inuiin (sinistrin) continuous infusion urinary clearance method... 

Inuiin (sinistrin) single bolus plasma clearance method " Cr-EDTA... 

The molecular weight distribution of sinistrin, a polysaccharide isolated from the bulbs of the red squill and which has been used for renal clearance, covered the range 8.0x10 to 1.6x10 . Viscosity measurements indicated a highly branched molecule in which residues of D-glucose were present at the reducing end of most molecules. 

It had previously been shown that renal function could be estimated through the measurement of dye clearance in conscious mice. These studies have been based on traditional approaches where inulin and the related derivative fructosan sinistrin, as well as diethylenetriamine pentaace-tate (DTPA), have been used in various forms as renal clearance substances (Silkalns et al., 1973 Goates et al., 1990 Jung et al 1992 McLachlan et al 2001). Their detection involved enzymatic or colorimetric measurements of inulin and sinistrin from serum or urine or scintigraphy of radiolabeled DTPA. 

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