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Single-stranded oligonucleotides pharmacokinetics

Among DNA-based drugs, only antisense DNA is currently analyzed by capillary electrophoresis. Antisense DNA therapy requires reliable and convenient methods for sequencing short single-stranded oligonucleotides. A method for phosphorothioate antisense DNA sequencing by capillary electrophoresis coupled to UV detection has been developed based on a modified chain-termination sequencing method.Capillary gel electrophoresis alone or in combination with HPLC is also used for pharmacokinetics study of antisense... [Pg.548]

See other pages where Single-stranded oligonucleotides pharmacokinetics is mentioned: [Pg.494]    [Pg.144]    [Pg.93]    [Pg.93]    [Pg.96]    [Pg.115]    [Pg.540]    [Pg.544]    [Pg.1130]    [Pg.46]    [Pg.42]    [Pg.296]   
See also in sourсe #XX -- [ Pg.542 , Pg.543 ]



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Single-stranded oligonucleotides

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