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Single-stranded antisense oligonucleotides

Antisense therapy means the selective, sequence-specific inhibition of gene expression by single-stranded DNA oligonucleotides. By hybridizing to the target mRNA, which results in a subsequent double-helix formation, gene expression is blocked. This process can occur at any point between the conclusion of transcription and initiation of translation or even possibly during translation. [Pg.185]

Single-Stranded Oligonucleotides Used for Antisense Activity 540... [Pg.537]

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Antisense

Antisense oligonucleotide

Antisense oligonucleotides

Antisense strand

Single-strand

Single-stranded

Single-stranded oligonucleotides

Single-stranded oligonucleotides antisense activity

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