Single reaction monitoring

Positive-ion single reaction monitoring Finnigan MAT API I ESI (electrospray ionization) 4.5 kV... 

Several scan modes are unique to the triple-quadrupole instrument, and most of these modes are superior in duty cycle versus an ion trap, Fourier transform (FT), or time-of-flight (TOF) mass spectrometers. Different elements of the triple-quadrupole perform different operations for each scan mode. These scan modes, each of which will be described in detail, are single-reaction monitoring (SRM) or multiple-reaction monitoring (MRM), precursor ion scanning (PIS), and constant-neutral-loss scanning (NLS). These scan modes and applications for structural elucidation have been described in detail (Yost and Enke, 1978, 1979). 

GC/MS/MS also allows the determination of scheduled chemicals in complex sample matrices with great selectivity and at low detection levels. Information by MS/MS can be obtained either by recording product (parent-daughter) ion spectra of a selected mass or by performing single reaction monitoring (SRM) or multiple reaction monitoring... 

In LC-MS/MS methods collision-induced dissociation (CID) of the PA molecular ion provides fragment ions that can be used in single reaction monitoring (SRM), or multiple reaction monitoring (MRM). CID produces characteristic ions at... 

Therefore, the target-compound monitoring based on mass spectrometry (MS) methods that use single reaction monitoring (SIM) or selected reaction monitoring (SRM) modes, is often insufficient to assess the quality of environmental water, because only a limited number of analytes are recorded (rarely more than 100 compounds), while unknown and potentially harmful micro-contaminants present might represent a threat to environment and human health. 

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