Single-pot synthesis

Scheme 6 Single-pot synthesis of sulfonic acid phosphine ligands...

A single-pot synthesis for complexes 117, 118 consists of reacting amides with a 1 3 mixture of hexamethyldisilazane and 116145. It was suggested that this reaction also proceeds in two consecutive steps as in Figure 15, but without the need to isolate intermediate products. 

Niobium and tantalum belong to the metals that are able to bind dinitrogen. The development of this area was first due to Schrock and coworkers, who in 1982 could obtain stable tantalum /X-N2 compounds in high yields by reducing Alkylidene complexes under dinitrogen at normal pressure.This route can be circumvented in a single pot synthesis by reacting the pentahalides with sUylated hydrazines (equation 12). 

The number of stages of derivatization for any functional group in organic compounds should be minimal (one or two, but no more). For multistage processes, the condition single-pot synthesis is necessary. Such operations as extraction or reextraction are permitted only when the quantities of... 

Yadav, G.D., Kirthivasan, N. 1995. Single-pot synthesis of methyl tert-butyl ether from tert-butyl alcohol and methanol Dodecatungstophosphoric acid supported on clay as an efficient catalyst. Journal of the Chemical Society, Chemical Communications (2) 203-204. 

Doherty, S., Knight, J.G., Smyth, C.H., Harrington, R.W. and Clegg, W. (2007) Rhodium-catalyzed double [24-24-2] cycloaddition of 1,4-bis (diphenylphosphinoyl)buta-l,3-diyne with tethered diynes a modular, highly versatile single-pot synthesis of NU-BIPHEP biaryl diphosphines. Organic Letters, 9(23), 4925-4928. 

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