Single-Line Interface Construction

From an analytical standpoint, we would ideally prefer to maintain discrete solvent lines even upon introduction into the mass spectrometer. This would ensure that continued data integrity throughout the analytical process could be maintained and no there would be constraints on sample adjacencies. We embarked on a technical collaboration with Micromass (UK) to develop and construct an interface into a mass spectrometer that would achieve our goal. The result of this collaboration is the construction of a novel four-channel multiplex electrospray liquid chromatography interface that has been used to analyze single components and quaternary mixtures by LC-MS as well as synthetic samples prepared by automated procedures. 

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