Single-gene inheritance

Diseases of people come in many flavors. There are infectious diseases (measles, mumps, influenza, AIDS,...), nutritional deficiency diseases (scurvy, beriberi, kwashiorkor,...), degenerative diseases (Alzheimer s disease, osteoporosis,...), cancer (of the lung, breast, prostate, liver,...), and single-gene inherited diseases or molecular diseases. In the last category, an important and instructive example is provided by sickle cell anemia. Let s consider this disease and begin to develop a sense of how we can understand it on the basis of what we now know about proteins. 

The late form of Pelizaeus-Merzbacher s disease which follows autosomal dominant single gene inheritance as established by Camp and L5wenberg (1941) and confirmed by Zbrbin-Rudin and Pbiffer (1964) is not accepted by Zeman et al. (1964) to belong to the disease entity described by Pelizaeus and Merz-... 

Lander and Schork s article was written against the backdrop of related investigations by 1990s geneticists, who also found that single-gene disorders were not so simple, even when inherited in a Mendelian way. Cystic... 

Some genetic conditions are caused by mutations in a single gene. These conditions are usually inherited in one of several straightforward patterns, depending on the gene involved ... 

Major modes of inheritance of single-gene mutations are ... 

Single-gene diseases have clear inheritance patterns. 

The inheritance patterns of multifactorial diseases differ from those of single-gene dborders in several important ways. 

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