Singer, Jonathan

On the basis of the dynamic properties of proteins in membranes, S. Jonathan Singer and Garth Nicolson proposed the concept of a fluid mosaic model for the overall organization of biological membranes in 1972 (Figure 1230). The essence of their model is that membranes are two-dimensional solutions of oriented lipids and globular proteins. The lipid bilayer has a dual role it is both a solvent for integral membrane proteins and a permeability barrier. Membrane proteins are free to diffuse laterally in the lipid matrix unless restricted by special interactions. 

Singer, S. Jonathan, and Nicolson, Garth L. (1972). The Fluid Mosaic Model of the Structure of Cell Membranes. Nature 175 720-731. 

Ott, J. 1978A. Mr. Jonathan Ott s Rejoinder to Dr. Alexander H. Smith. Ethnomycol-ogical Studies No. 6. Botanical Museum of Harvard University, Cambridge, ma. Introducing Mr. Ott by R. G. sS sson, p. I. Rebuttal to A.H. Smith 1977. See also Singer 1982 Whsson 1982A. 

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