Simocyclinone

Schimana J, Fiedler H-P, Groth I, Siissmuth R, Beil W, Walker M, Zeeck A (2000) Simocyclinones, Novel Cytostatic Angucyclinone Antibiotics Produced by Streptomyces antibioticus Tii6040 I. Taxonomy, Fermentation, Isolation and Biological Activities. J Antibiot 53 779... 

Holzenkampfer M, Zeeck A (2002) Biosynthesis of Simocyclinone D8 in an 1802-rich Atmosphere. J Antibiot 55 341... 

A known strain of S. antibioticus was found to produce a compound designated simocyclinon D8 (44) [31]. The compound exhibits antibiotic activity against Gram-positive bacteria and cytostatic effects against various cancer cells. Its structure and biosynthesis were clarified on the basis of physical-chemical methods, mainly by ID and 2D NMR and ESI-MS. It was found that during its biosynthesis the incorporation of 180 into the aminocoumarine residue is probably catalyzed by a monooxygenase. 

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