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Simocyclinon

Schimana J, Fiedler H-P, Groth I, Siissmuth R, Beil W, Walker M, Zeeck A (2000) Simocyclinones, Novel Cytostatic Angucyclinone Antibiotics Produced by Streptomyces antibioticus Tii6040 I. Taxonomy, Fermentation, Isolation and Biological Activities. J Antibiot 53 779... [Pg.449]

Holzenkampfer M, Zeeck A (2002) Biosynthesis of Simocyclinone D8 in an 1802-rich Atmosphere. J Antibiot 55 341... [Pg.449]

A known strain of S. antibioticus was found to produce a compound designated simocyclinon D8 (44) [31]. The compound exhibits antibiotic activity against Gram-positive bacteria and cytostatic effects against various cancer cells. Its structure and biosynthesis were clarified on the basis of physical-chemical methods, mainly by ID and 2D NMR and ESI-MS. It was found that during its biosynthesis the incorporation of 180 into the aminocoumarine residue is probably catalyzed by a monooxygenase. [Pg.319]

See other pages where Simocyclinon is mentioned: [Pg.310]    [Pg.311]    [Pg.228]    [Pg.319]    [Pg.230]    [Pg.319]    [Pg.296]    [Pg.297]   
See also in sourсe #XX -- [ Pg.319 ]

See also in sourсe #XX -- [ Pg.319 ]

See also in sourсe #XX -- [ Pg.29 , Pg.319 ]



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Oxygen compounds of simocyclinon

Simocyclinon antibiotic activity

Simocyclinon biosynthesis

Simocyclinon cytostatic effects

Simocyclinon structure

Simocyclinone

Simocyclinone

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