Silylating agent

Derivatizing an organic compound for analysis may require only a few drops of reagent selected from silylating kits suppHed by laboratory supply houses. Commercial synthesis of penicillins requites silylating agents purchased in tank cars from the manufacturer (see Antibiotics, P-LACTAMS-PENICILLINS AND others). 

Chemical name CAS Registry Number Common abbreviation Formula 

AT-methyl- /V-trimethyl-silylttifluoroacetami de /-butyl dimethyl silylimid- azole [24589-78-4] MSTFA (CH3)3SiN(CH3)COCF3 

The chlorosilanes are clear Hquids that should be treated as strong acids. They react readily with water to form corrosive HCl gas and Hquid. Liquid chlorosilanes and their vapors are corrosive to the skin and extremely irritating to the mucous membranes of the eyes, nose, and throat. The nitrogen-functional silanes react with water to form ammonia, amines, or amides. Because ammonia and amines are moderately corrosive to the skin and very irritating to the eyes, nose, and throat, silylamines should be handled Kke organic amines. Trimethylsilyl triduoromethanesulfonate and trimethylsilyl iodide form very corrosive acidic products. 

The techniques of silylation and their appHcation in analysis have been reviewed (1,2), as have the intermediate steps in organic synthesis (3). Summaries of silylation appHcations are available (4,5). 

Kirk-Othmer Encyclopedia of Chemical Technology (4th Edition) 

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SAN copolymers in [ACRYLONITRILE POLYTffiRS - SURVEY AND SAN (STYRENE-ACRYLONITRME CO-POLYTffiRS)] (Vol 1) -silylating agents for [SILICON COMPOUNDS - SILYLATING AGENTS] (Vol 22)... 

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