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Silyl enol ethers with aryl Grignard reagents

The introduction of a t-butyl group a - to a carbonyl group has been achieved by Friedel-Crafts alkylation of the appropriate trimethylsilyl enol ether. In the presence of a nickel(ii) catalyst, u/c-bromotrimethylsilyloxyalkenes couple with Grignard reagents to produce alkylated and arylated silyl enol ethers, which, after hydrolysis, furnish the corresponding a-alkylated or a-arylated ketones (Scheme 36). ... [Pg.42]

Azodicarboxylate esters are the reagents of choice for electrophilic A -amino aminadon leading to hydrazine derivatives. Besides Grignard reagents and alkyl or aryl lithiunt conqmunds, enolates and silyl enol ethers derived from ketones have been aminated by this method. In particular, di-r-butyl az icarboxylate has been reacted with a variety of chiral enolates (Scheme I9)i03.i04 chiral silyl ketene acetals (Schemes 20 and to afford a-hydrazino acid derivatives with high dia-... [Pg.118]

See other pages where Silyl enol ethers with aryl Grignard reagents is mentioned: [Pg.461]    [Pg.58]    [Pg.286]    [Pg.1301]    [Pg.492]    [Pg.498]    [Pg.205]   
See also in sourсe #XX -- [ Pg.3 , Pg.492 ]

See also in sourсe #XX -- [ Pg.492 ]

See also in sourсe #XX -- [ Pg.3 , Pg.492 ]



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Aryl Grignard reagents

Aryl Grignards

Aryl ethers

Aryl silyl enol ethers

Aryl silylation

Arylating reagents

Arylation reagents

Arylations enolates

Enol ethers arylation

Enol ethers reagent

Enolates arylation

Enolates silylation

Ethers, aryl silyl

Ethers, silyl enol reagents

Grignard reagents arylation with

Grignard reagents silyl

Grignard reagents with ethers

Silyl enol ethers

Silyl enolate

Silyl enolates

Silyl enolates arylation

Silyl reagents

Silylation reagent

With Grignard Reagents

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