Signs and Symptoms Index

TSH, T3, T, T3-resin uptake, free thyroxin index), but careful attention to early signs and symptoms of hypofunction (e.g., weight gain, cold intolerance, hair loss) may be more productive. Thyroid-stimulating hormone is sensitive to early thyroid changes and, if elevated, should prompt treatment with thyroid supplements to avoid goiter or hypothyroidism. 

Tangier disease is an extremely rare genetic disorder with fewer than 100 cases reported since the index cases in 1961. Clinical signs and symptoms are variable and may depend on the age of the patients. For instance, signs of neuropathy were not observed in T. L. and E. L., in contrast to our 32-year-old patient. Assmann and colleagues (2001) have succinctly compiled the reported findings (Table 15-1), most of which are discussed here. 

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