Significance in Aging Processes

The formation of post-Amadori glycosylation rearrangement products and yellow-brown pigments is a reflection of normal blood glucose concentra- 

Interest in the subject was initiated in 1974 while the author was head of the Metabolic Research and Human Biochemical Genetics Unit, South African Institute for Medical Research (SAIMR), Johannesburg. Literature to June 1986 has been consulted. I am indebted to Ronald Georges, head of Biochemical Methods and Equipment Unit, SAIMR, for many fruitful discussions and material assistance in obtaining reference material. 

Abraham, E. G., Glycosylated Hemoglobins Methods of Analysis and Glinical Applications. Dekker, New York, 1985. 

Abraham, E. C., Stallings, M., Abraham, A., andClardy, R., Demonstration of a minor hemoglobin with modified a chains and additional modified hemoglobins in normal and diabetic adults. Biochim. Biophys. Acta 744, 335-341 (1983). 

Aeharya, A. S., and Sussman, L. G., The reversibility of the ketoamine linkages of aldoses with proteins. J. Biol. Chem. 259, 4372-4378 (1984). 

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