Signaling transduction paradigms

J. C. Sacchettini, L. G. Baum, and C. F. Brewer, Multivalent protein-carbohydrate interactions. A new paradigm for supermolecular assembly and signal transduction, Biochemistry, 40 (2001) 3009-3015. 

Martinez-Ruiz, A., Lamas, S., S-nitrosylation a potential new paradigm in signal transduction. Cardiovasc. Res. 62 (2004), p. 43-52... 

Schwartz MA, Schaller MD, Ginsberg MH. Integrins Emerging paradigms of signal transduction. Ann Rev Cell Dev Biol. 1995 11 549-599. 

Thus, the IFN signaling model represents a paradigm for the functioning of many other cytokine receptors that utilize the JAK/STAT pathway for intracellular signal transduction (Ihle, 1996). The importance of individual members of the JAK kinase family and individual STAT proteins varies depending on the specific cytokine involved, but the basic principles remain the same. 

In attempts to further understand the signal transduction cascades that regulate capacitation, our laboratory has recently correlated mouse, human, and bovine sperm capacitation with an increase in protein tyrosine phosphorylation of a variety of substrates (Visconti et ah, 1995a Carrera et ah, 1996 Galantino-Homer et ah, 1997). Many of these results have since been corroborated by other labs (Aitken et ah, 1995 Leclerc et ah, 1996 Luconi et ah, 1996 Emiliozzi and Fenichel, 1997). Using the mouse as an experimental paradigm, our laboratory has demonstrated... 

Dohlman, H. G., and J. W. Thorner. 2001. Regulation of G protein initiated signal transduction in yeast paradigms and principles. Ann. Rev. Biochem. 70 703-754. 

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