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Signal transduction requirements

Signal transduction requires the presence of the P-chain. 1L-3-IL-3R interaction results in rapid phosphorylation of several cellular proteins, including the IL-3RP-subunit itself. ... [Pg.665]

A recent study showed that trophinin not only functions as an adhesion molecule but also plays a role in signal transduction required for ErbB4 activation in human trophoblastic cells (42,43). Thus, trophinin has an activity responsible for its ability to transform silent trophectoderm cells into an aggressive trophoblast for... [Pg.295]

The spatial and steric requirements for high affinity binding to protein kinase C (PKC), a macromolecule that has not yet been crystallized, were determined. Protein kinase C plays a critical role in cellular signal transduction and is in part responsible for cell differentiation. PKC was identified as the macromolecular target for the potent tumor-promoting phorbol esters (25). The natural agonists for PKC are diacylglycerols (DAG) (26). The arrows denote possible sites of interaction. [Pg.240]

A signal transduction pathway required for proper chromosome alignment during mitosis. The spindle assembly checkpoint is activated during mitosis in response to the presence of chromosomes that are not attached to spindle microtubules or that are not properly aligned at the metaphase plate. The spindle checkpoint... [Pg.1154]

Gartner, A., Nasmyth, K., and Ammerer, G. (1992). Signal transduction in Saccharomyces cerevisiae requires tyrosine and threonine phosphorylation of FUS3 and KSS1. Genes Dev. 6 1280-1292. [Pg.40]

Zhou, Z., Gartner, A., Cade, R., Ammerer, G., and Errede, B. (1993). Pheromone-induced signal transduction in Saccharomyces cerevisiae requires the sequential function of three protein kinases. Mol. Cell. Biol. 13 2069-2080. [Pg.53]

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