Signal transduction evolution

M. Rodbell, Signal-Transduction - Evolution of an Idea (Nobel Lectme) , Angew. Chem. Int. Ed., 34,1420 (1995)... 

Rodbell M (1995). Nobel lecture signal transduction Evolution of an idea. Biosci Rep 15 117—133. 

M. Rodbell, Nobel lecture. Signal transduction evolution of an idea, Biosci. Rep. 1995, 15, 117-133. 

A tremendous effort has been made by scientists to understand and to mimic the most fascinating and inaccessible of the organs developed by evolution. In spite of the efforts devoted to observing and understanding the morphology of the different components of the nervous system, the conformational structure of the amorphous channels responsible for signal transduction remains unsolved. Nevertheless, the main problem related to the nervous system is centered on the nervous impulse how it is formed, how many components it has, what kind of information drives every component, and how we can interact with these components in order to... 

Other proteins crucial to signal-transduction pathways arose much later. For example, the eukaryotic protein kinases are one of the largest protein families in all eukaryotes and yet appear to be absent in prokaryotes. The evolution of the eukaryotic protein kinase domain appears to have been an important biochemical step in the appearance of eukaryotes and the subsequent development of multicellular organisms. 

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