Signal patterns in proton spectra of skeletal muscle

SIGNAL PATTERNS IN PROTON SPECTRA OF SKELETAL MUSCLE 

Proton spectra of normal human skeletal muscle are dominated by the signal of water. Other metabolites contribute with clearly less than 10% to the 

In water-suppressed muscle spectra, contributions of lipids, methyl and methylene groups of creatine (Crs, Cr2), trimethylammonium-containing compounds (TMA), including signals from carnitine (Ct), choline (Cho), and taurine (Tau) are well observable as demonstrated in Fig. 15. Furthermore, small signals of histidine protons of carnosine (Cs) can be sometimes identified 

The basic physical NMR phenomena leading to changes of the appearance of these resonances in muscular proton spectra are briefly described in the following sections. 

Separation of EMCL and IMCL in proton muscle spectra is possible due to the different geometrical arrangement of these lipid compartments resulting in different bulk magnetic susceptibility (BMS). EMCL are nestled in long fatty septa along the muscle fibre bundles or fasciae, and can thus be described in a simplified way as coaxial cylinders. IMCL are located in a roughly spherical 

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Signal Patterns in Proton Spectra of Skeletal Muscle 19... 

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