SIEF Substance Information Exchange

MoS Margin of safety SIEF Substance information exchange forum... 

Where there are two or more manufacturers/importers of the same substance, they are required to form a Substance Information Exchange Forum (SIEF). Forming a SIEF is not optional, and companies that refuse to join, or to cooperate, may lose their authority to market the substance. The SIEF will consider the need for additional testing, particularly testing that requires the use of animals, to avoid duplication of effort. 

On 30 October 2008, the European Commission (EC) circulated a draft document regarding the registration of nanomaterials under REACH [17]. According to the EC, the aim of this document is to address the key questions related to the registration of nanomaterials in REACH in order to advise on how to deal with nanomaterials in the registration and in the related discussions in pre- Substance Information Exchange Forum (SIEF) and in SIEF in coherent and comparable manner. [18]... 

The Agency intends to create a substance information exchange foram (SIEF). SIEF will allow the exchange of information on the study summaries between manufacturers and importers of the same substance in order to avoid duplication of studies and to harmonize classification and labelling. 

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