Side-effects toxic

Imipramine3 10-25 75-250 cardiovascular effects delayed onset of action may precipitate mania sexual side effects toxic in overdose weight gain... 

Information and claims about side-effects must reflect available evidence or be capable of substantiation by clinical experience. It must not be stated that a product has no side-effects, toxic hazards or risks of addiction. The word safe must not be used without qualification. 

FU has been extensively used in the treatment of skin cancers and a variety of solid tumours, such as breast, colorectal and gastric cancers, usually via intravenous (i.v.) administration. Although this route is generally the most efficient and the least toxic, it is costly and inconvenient [87], Furthermore, treatment of cancer with 5-FU has been found to cause neurotoxic and cardiotoxic side effects. Toxicity also derives from the lack of selectivity of the drug towards tumours, and resistance can occur if the cell produces excess of dump, for competing with the drug in the active site [88]. 

In spite of much effort that has been put into reducing the side-effects, toxicity remains a major limitation of the clinical use of platinum complexes in anticancer therapy [26][27] [29] [30] and several compounds termed rescue agents , or protective agents have been investigated for co-administration with platinum compounds in order modulate these side effects of platinum therapy. 

CARBAMAZEPINE GRAPEFRUIT JUICE t efficacy and t adverse effects Grapefruit juice irreversibly inhibits intestinal CYP3A4. Transport via P-gp and the MRP-2 efflux pumps is also inhibited Monitor fort side-effects/toxicity and check carbamazepine levels. If levels or control of fits are variable remove grapefruit juice and grapefruit from the diet... 

The main role of the kidney in the process of drug metabolism consists in the excretion of the many, more or less pharmacologically active metabolites formed in the liver [8]. Needles to say that renal insufficiency may result in the accumulation of metabohtes and, if pharmacological active, may result in serious side effects/ toxicity [33]. Renal metabolism of drug-xenobiotics and its contribution to elimination has been inadequately explored so that clinical implications are for the most part inferred from animal models or speculative. 

It must not be stated that a product has no side effects, toxic hazards or risks of addiction or dependency. 

Hazard May have adverse side effects toxic in overdose. 

During the study the health of volunteers should be monitored so that onset of side-effects, toxicity, or any intercurrent disease may be recorded, and... 

Drug Metabolism and Excretion versus Side-Effect Toxicity... 

Side effects, toxicity, and conditions that alter sensitivity, as well as the treatment of acute intoxication, are similar to those described for morphine. During long-term administration, there may be excessive sweating, lymphocytosis, and increased concentrations of prolactin, albumin, and globulins in the plasma. Rifampin and phenytoin accelerate the metabolism of methadone and can precipitate withdrawal symptoms. 

Among the earliest reported noncopper SOD mimics are porphyrinato Fe(III) and Mn(III) complexes described by Pasternack and coworkers 16a), whereas the catalytic and biological function of Mn(III)porphyrins is covered by Duke University patents 16b-d). The metal porphyrin complexes as potential human pharmaceuticals suffer from a nmnber of possible lethal side effects (toxicity due to the DNA/RNA nicking... 

Long half-lives - harder to clear/stop if side effects toxicity can build... 

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