Side-chain functionalized supramolecular motifs

Rotello and coworkers [30] reported the first PNBE-based random copolymers with nucleobase-functionalized side chains, wherein longer linkers were utilized to achieve solubility. The system relied upon the complementary three-point H-bonding motif between uracil and diacyl DAP pendant groups on two respective polymer chains (figure 4.5a). The resulting side-chain-functionalized supramolecular polymers self-assemble into spherical polymersomes (figure 4.5b). 

The previous section described the supramolecular side chain functionalization of polymers based on a single recognition motif. However, biological systems use a wide variety of noncovalent interactions such as hydrogen bonding, metal coordination, and hydrophobic interactions in an orthogonal fashion to introduce function,... 

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