Sialyltransferases Catalyzing Sialooligosaccharides and Sialoglycoprotein Biosynthesis

At least six SATs (Table I) have been characterized as having importance in the biosynthesis of the major sialic acid linkages found in mammalian oligosaccharides and glycoproteins. 

Substrate Linkage of sialic acid to terminal sugar Nomenclature References 

Gaipi-4Glc (lactose) Galpl-Glc 3 a 2 NeuAc r Jourdian et al. (1963), Kaufman and Basu (1966), Carlson et al. (1973a), S. Basu (1966) 

Galpl-4GicNAc j or iNGP 6 InGP NeuAc Bartholomew et al. (1973), Paulson et al. (1977a,b), Weinstein et al. (1982), Datta and Paulson (1995) 

Gaipi-4GlcNAc Or iNGP, 3 12 NeuAc Dijak et al. (1979), Kitagawa and Paulson (1993a,b), Sasaki et al. (1993) 

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