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Sialyltransferases brain

Figure 6. Effect of CMP-NeuAc concentration (V/S), of pH (V/pH), of enzymatic protein concentration (V/protein), and of incubation time (V/t) on the activity of synaptosomal membrane-bound sialyltransferase. Calf brain cortex. Acceptor substrates for sialyltransf erase (if) lactosylceramide ( ) desialylated fetuin (%) endogenous glycoprotein (endogenous glycolipids. Figure 6. Effect of CMP-NeuAc concentration (V/S), of pH (V/pH), of enzymatic protein concentration (V/protein), and of incubation time (V/t) on the activity of synaptosomal membrane-bound sialyltransferase. Calf brain cortex. Acceptor substrates for sialyltransf erase (if) lactosylceramide ( ) desialylated fetuin (%) endogenous glycoprotein (endogenous glycolipids.
Specificity and Membrane Properties of Young Rat Brain Sialyltransferases... [Pg.345]

It was apparent, however, that the rat brain sialyltransferases have not been sufficiently characterized for the postulation of a biological role for the sialylation-desialylation cycle. Consequently, we concentrated our efforts to characterizing the general behaviors of the sialyltransferases in their membrane environments in the rat brain. What follows is a summary of our... [Pg.345]

Whereas the activities of CMP-NeuNAc lactosylceramide sialyltransferase increase postnatally (38), the activities of the CMP-NeuNAc glycoprotein sialyltransferase decline dramatically during early development (17). Separate regulatory controls on the glycoprotein and glycolipid metabolism have also been implicated in a study on the brain tissues of Tay-Sachs disease patients. [Pg.350]

A continuous sucrose gradient of the total homogenate from young rat brain and electron microscopic examination of these fractions found most of the sialyltransferase activities to be localized in smooth microsomal membrane and Golgi complex derivatives and not associated with synaptosomes. [Pg.356]

Preuss U, Gu X, Gu T, Yu RK. Purification and characterization of CMP-N-acetylneuraminic acid lactosylceramide (alpha 2-3) sialyltransferase (GM3-synthase) from rat brain. J. Biol. Chem. 1993 268 26273-26278. [Pg.422]

Lee YC, Kurosawa N, Hamamoto T, Nakaoka T, Tsuji S (1993) Molecular cloning and expression of Gal/il,3GalNAc a2,3-sialyltransferase from mouse brain. Eur J Biochem 216 377-385... [Pg.1690]

Yoshida Y, Kojima N, Kurosawa N, Hamamo-to T, Tsuji S (1995) Molecular cloning of Sia o 2,3Gal l,4GlcNAc a2,8-sialyltransferase from mouse brain. J Biol Chem 270 14628-14633... [Pg.1691]

Values are the mean of two experiments. Absolute values per g of brain were ganglioside NeuNAc, 1.4 /imol endogenous acceptor capacity (E A C), 245.616 cpm of n-NeuNAc incorporated into endogenous gangliosides after 60 min of incubation of membranes with CMP- H-NeuNAc CMP-NeuNAc lactosylceramide sialyltransferase activity (STA), 3,380,951 cpm of H-NeuNAc incorporated into lactosylceramide after 60 min of incubation with CMP-3H-NeuNAc. Relative concentration (RC) means ... [Pg.270]

Lactosylceramide sialyltransferase (step 2) was originally detected in embryonic chicken brain (Kaufman ef al. 1968), has also been found in calf brain (Pretic al... [Pg.221]

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See also in sourсe #XX -- [ Pg.221 , Pg.222 ]



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