Sialylated glycoconjugate

Whereas for a long time the main function of terminal sialic acid residues was considered as a mask for recognition sites on cell surfaces, e.g. galactose residues or antigens as outlined above, it is only in the last few years that receptors have been described which connect the structural diversity of sialylated glycoconjugates to specific functions in cellular interactions. 

Blood (factor H of alternate complement pathway) sialylated glycoconjugates, other polyanionic molecules [1018]... 

Damoiseaux JG, Dopp EA, Dijkstra CD (1991) Cellular binding mechanism on rat macrophages for sialylated glycoconjugates, inhibited by the monoclonal antibody ED3. J Leukoc Biol, 49 434-441. 

CatA deficiency or mutations affecting the structural integrity of CatA, therefore, lead to accumulation of sialylated glycoconjugate substrates of Neu-1 and later to the severe genetic disease galactosialidosis [10]. Common clinical signs are massive edema, skeletal dysplasia, cherry red spots on the retina, and neurological deterioration. 

Crocker, P. R., and Gordon, S., 1989, Mouse macrophage hemagglutinin (sheep erythrocyte receptor) with specificity for sialylated glycoconjugates characterized by a monoclonal antibody, J. Exp. Med. 169 1333-1346. 

Ishikawa, H., and Isayama, Y., 1987, Evidence for sialyl glycoconjugates as receptors for Bordetella bronchiseptica on swine nasal mucosa. Infect. Immun. 55 1607-1609. 

Within the last three decades tremendous advances have been made in our understanding of the structure and biosynthesis of sialylated glycoconjugates by mammalian cells and E. coli K12. To understand strict specificity of a gly-cosyltransferase and the structure of its catalytic products (mucin, glycoprotein. 

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