Sialyl glycosides synthesis

This versatile method, designed for the regio- and a-stereoselective sialyl glycoside synthesis, has been further developed to the oligosialyl glycoside synthesis. 

Figure 2 An efficient regio- and a-stereoselective synthesis of mono-sialyl glycosides. (SE = —CH2CH2SiMe3.)...

Figure 3 An efficient regio and a-stereoselective synthesis of oligo-sialyl glycosides.

AFP. See Antifreeze proteins (AFPs) Aglycones and aglycone reactions. See Natural C-glycosides Ramberg-Backlund reaction Reverse polarity (umpolung) approach to aryl C-glycoside synthesis Sialyl Lewis X (sLex)... 

Sialic acids are involved in a number of biological processes including cell-to-cell, cell-to-microorganism, -toxin, and -antibody binding. Their importance in these processes, especially those with relevance to human disease states, has led to interest in the synthesis of both natural and modified sialic acids. This review examines the most recent methods used for the synthesis and modification of sialic acids and for the preparation of sialyl glycosides as biological probes of sialic acid-recognising proteins. 

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