Sialidases apoptosis

M. S. Leguizamon, E. Mocetti, H. Garcia Rivello, P. F. Argibay, and O. Campetella, trans-sialidase from Trypanosoma cruzi induces apoptosis in cells from the immune system in vivo, J. Infect. Dis., 180(1999) 1398-1402. 

J. Mucci, M. G. Risso, M. S. Leguizamon, A. C. C. Frasch, and O. Campetella, The trans-sialidase from Trypanosoma cruzi triggers apoptosis by target cell sialylation, Cell Microbiol., 8 (2006) 1086-1095. 

The possibihty that the sialylation level of glycoproteins is cracial for tiie shift from apoptosis to malignant proliferation is an intriguing working hypofliesis, and opens new perspectives in therapeutieal approaches for ehronic myeloid leukemia based on the eytosolie sialidase NEU2 expression. 

C. Tringali, B. Lupo, L. Anastasia, N. Papini, E. Monti, R. Bresciani, G. Tettamanti, and B. Venerando, Expression of sialidase Neu2 in leukemic K562 cells induces apoptosis by impairing Bcr-AbESrc kinases signaling, J. Biol. Chem., 282 (2007) 14364-14372. 

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