Short sequence length polymorphisms

A third type of polymorphism is due to tandem repeats of short sequences that can be detected by PCR-based analysis. These are known variously as microsatellites, short tandem repeats (STRs), STR polymorphisms (STRPs), or short sequence length polymorphisms (SSLPs). These repeat sequences usually consist of two, three, or four nucleotides and are plentiful in most organisms. All PCR-converted STR markers (those for which a pair of oligonucleotides flanking the polymorphic site suitable for PCR amplification of the locus has been designed) are considered to be STSs. The advent of PCR-based analysis quickly made microsatellites the markers of choice for mapping. 

Mapping of eukaryotic chromosomes has involved additional methods which are discussed in Sections E and G,l. These incluse radiation hybrid mapping,104 use of meiotic recombination, identification of restriction fragment length polymorphisms (RFLPs described in Section E,7), and use of expressed sequence tags (ESTs), short DNA sequences deduced from mRNA molecules transcribed from the DNA.105 106... 

RFLP(s), Restriction Fragment Length Polymorphism(s) see, Sequence Compositional Complexity sd, standard deviation SINE(s), Short Interspersed Repeat(s)... 

Schouls, L.M., Reulen, S., Duim, B., et al. (2003) Comparative genotyping of Can y/obacteryguni by amplified fragment length polymorphism, multilocus sequence typing, and short repeat sequencing strain diversity, host range, and recombination. J Clin Microbiol 41,15-26. 

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