Shikimic acid antitumoral activity

Pericosine B, a secondary metabolite produced by a strain of Periconia bissoides [48], proved to be an interesting target compound due to its significant antitumoral activity. From a structural point of view, pericosine B (201, Scheme 33) can be considered as an unsaturated carbauronic acid or an hydroxylated shikimic acid derivative. 

An ansamycin antibiotic produced by Streptomyces spectabilis with antibacterial (against tuberculosis pathogens), antiviral, and antitumor activities. S. occurs as a multi-component mixture of up to ten individual compounds (S. A to G, J, K, and U) with S. C (methyl streptovaricate, C4oH5,NO,4, Mr 769.84, amorphous, mp. 189-191 °C, [a][) 4-602°) as the main component. The S. are inhibitors of bacterial RNA-polyme-rase as well as the reverse transcriptase of oncogenic viruses. The biosynthesis of the aromatic core branches off from the shikimic acid pathway while the alkyl chain is formed on the polyketide pathway. 

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