Shikimate 3-phosphase Synthase EPSPS

Inhibitors of 5-enolpyruvyl Shikimate 3-phosphase Synthase (EPSPS) 

Claire A. Cajacob, Paul C.C. Feng, Steven E. Reiser, and Stephen R. Padgette 

EPSPS is the sixth enzyme in the shikimate pathway that leads to the biosynthesis of aromatic amino acids, tryptophan, tyrosine, and phenylalanine. These aromatic amino adds along with intermediates of the pathway give rise to important secondary metabolites commonly referred to as phenylpropanoids that include phenolics, lignins, tannins, phytoalexins, etc. [1]. The shikimate pathway is localized in plastids and EPSPS is a key enzyme in regulating the flux through the pathway. 

EPSPS is found in plants, fungi and bacteria [3]. As a result glyphosate shows broad spectrum adivity against most plant species. Owing to the absence 

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Inhibitors of S-enolpyriivyl Shikimate 3-phosphase Synthase (EPSPS) 299 6.2A.2 Roundup Ready Com... 

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