Sharpless-Katsuki asymmetric epoxidation Synthetic Utility

The Sharpless-Katsuki asymmetric epoxidation (AE) procedure for the enantiose-lective formation of epoxides from allylic alcohols is a milestone in asymmetric catalysis [9]. This classical asymmetric transformation uses TBHP as the terminal oxidant, and the reaction has been widely used in various synthetic applications. There are several excellent reviews covering the scope and utility of the AE reaction... [Pg.188]

The synthetic utility of the oxirane technology was further extended by the development by Sharpless and Katsuki [33, 34] of the titanium(lV) tartrate catalyst for the asymmetric epoxidation of allylic alcohols with TBHP (eq. (16)). [Pg.420]

The first practical asymmetric epoxidation was reported by Katsuki and Sharpless.416 The catalyst that was used in the epoxidation of allylic alcohols by (Bu O was prepared in situ with Ti(OlV)4 and diethyltartrate. Since then, synthetic applications and mechanistic details of these reactions have been widely explored and utilized.564,565 Only a sampling of relevant reports have been cited.416,566-575... [Pg.59]

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