Serum sickness drugs involved

Type III Drugs may cause serum sickness, which involves immune complexes containing IgG and is a multisystem complement-dependent vasculitis that may also result in urticaria. 

Most anaphylactoid reactions are due to a direct or chemical release of histamine, and other mediators, from mast cells and basophils. Immune-mediated hypersensitivity reactions have been classified as types I-IV. Type I, involving IgE or IgG antibodies, is the main mechanism involved in most anaphylactic or immediate hypersensitivity reactions to anaesthetic drugs. Type II, also known as antibody-dependent hypersensitivity or cytotoxic reactions are, for example, responsible for ABO-incompatible blood transfusion reactions. Type III, immune complex reactions, include classic serum sickness. Type IV, cellular responses mediated by sensitised lymphocytes, may account for as much as 80% of allergic reactions to local anaesthetic. 

C. Type III Drug Allergy Type III hypersensitivity is a complex type of drug allergy reaction that involves complement-fixing IgM or IgG antib ies and—possibly—IgE antibodies. Drug-induced serum sickness and vasculitis are examples of type III reactions Stevens-Johnson syndrome (associated with sulfonamide therapy) may also result from type III mechanisms. 

Table 3. Drugs frequently involved in serum-sickness-like reactions. (Adapted from van Arsdel 1978)...

Type in hypersensitivity is mediated by soluble immune complexes mostly involving IgG antibodies. Drug-induced serum sickness-like reaction is the prototype example of type III drug hypersensitivity. Hypersensitivity vascu-Ms is another example of a type III hypersensitivity response induced by drugs. 

---