Bactericidal titers, serum

Serum bactericidal titer The lowest titer of serum and antibiotic obtained from the patient, usually at the peak or trough of antibiotic administration, that results in a 99.9% kill of bacteria. 

The evaluation of patients treated for IE includes assessment of signs and symptoms, blood cultures, microbiologic tests (e.g., MIC, minimum bactericidal concentration [MBC], or serum bactericidal titers), serum drug concentrations, and other tests to evaluate organ function. 

Serum bactericidal titers may be useful only when the causative organisms are moderately susceptible to antimicrobials, when less well-established regimens are used, or when response to therapy is suboptimal and dosage escalation is considered. 

Israel, D. Gillum, G. Turik, M. Harvey, K Ford, J. Dalton, H. Towle, M. Echols, R. Heller, A.H. Polk, R. Pharmacokinetics and serum bactericidal titers of ciprofloxacin and ofloxacin following multiple oral doses in healthy volunteers. Antimicrob.Agents Chemothen, 1993, 37, 2193-2199 [serum urine extracted ofloxacin fluorescence detection LOD 50 ng/mL]... 

Serum bactericidal titers In certain infections in which host defenses may contribute minimally to cure, the estimation of serum bactericidal titers can confirm the appropriateness of choice of drug and dosage. Serial dilutions of serum are incubated with standardized quantities of the pathogen isolated from the patient killing at a dilution of 1 8 is generally considered satisfactory. 

Van der Auwera R Ex vivo study of serum bactericidal titers and killing rates of daptomycin (LYI46032) combined or not combined with amikacin compared with those of vancomycin. Antimicrob Agent Chemother 1989 33 1783-1790. 

Describe the importance of susceptibility testing and analyses of serum drug levels or bactericidal titers in antimicrobial chemotherapy. 

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