Sertoli-Leydig cell tumor

FIGURE 18.28 Endometrioid carcinoma, including its Sertoliform variant, shows diffuse strong staining for epithelial membrane antigen (EMA). Sertoli cell and Sertoli-Leydig cell tumors are EMA negative. [Pg.727]

Immunohistochemical stains are important in the diagnosis of Sertoli-Leydig cell tumors because the various cell types can be difficult to recognize and because other tumor types, especially the Sertoliform variant of endometrioid carcinoma, share some histologic features with Sertoli-Leydig cell tumors. Sertoli cells stain for cytokeratin, which highlights tubules and delineates cords, nests, and sheets of immature Sertoli cells, but they are EMA-negative (Fig. The stromal... [Pg.734]

Heterologous elements are present in about 20% of Sertoli-Leydig cell tumors, and immunostains can help with their identification and classification. Gastrointestinal... [Pg.734]

The uncommon Sertoliform variant of endometrioid carcinoma is generally cytokeratin- and EMA-positive and lacks staining for inhibin or calretinin. Positive staining for inhibin and calretinin and lack of staining for EMA helps to differentiate between a Sertoli-Leydig cell tumor and the Sertoliform variant of endometrioid carcinoma (see Table 18.7).474,545,546,550 Sertoli-... [Pg.734]

Leydig cell tumors with pseudoendometrioid tubules almost invariably contain at least focal areas of more typical Sertoli-Leydig cell tumor morphology, and the pseudoendometrioid tubules show positive staining for inhibin and calretinin, and lack staining for EMA. ... [Pg.734]

They lack the primitive stroma and Leydig cells that are present in Sertoli-Leydig cell tumors. Oxyphilic and lipid-rich variants have been described, and Sertoli cell tumors can contain areas of diffuse growth. Immu-nohistochemistry can help to confirm the diagnosis and to differentiate a Sertoli cell tumor from such differential diagnostic considerations as Sertoliform endometrioid... [Pg.734]

FIGURE 18.38 Sertoli-Leydig cell tumor. This tumor shows focal heterologous hepatic differentiation in which the hepatocytic cells show strong cytoplasmic staining for AFP they also stained with anti-hepatocyte antibody. [Pg.735]

Hammad A, Jasnosz KM, Olson PR. Expression of alpha-fetoprotein by ovarian Sertoli-Leydig cell tumors—Case report and review of the literature. Arch Pathol Lab Med. 1995 119 1075-1079. [Pg.756]

Mooney EE, Nogales FF, Tavassoli FA. Hepatocytic differentiation in retiform Sertoli-Leydig cell tumors distinguishing a heterologous element from Leydig cells. Hum Pathol. 1999 30 611-617. [Pg.756]

Farinola MA, Gown AM, Judson K, et al. Esttogen teceptor alpha and progesterone receptor expression in ovarian adult granulosa cell tumors and Sertoli-Leydig cell tumors. Int J Gynecol Pathol. 2007 26 375-382. [Pg.759]

Young RH, Sctrlly RE. Well-differentiated ovarian Sertoli-Leydig cell tumors A clinicopathological analysis of 23 tumots. Int J Gynecol Pathol. 1984 3 277-290. [Pg.759]

Young RH, Scully RE. Ovarian Sertoli-Leydig cell tumors with a retiform pattern—A problem in diagnosis A report of 25 cases. Am J Surg Pathol. 1983 7 755-771. [Pg.759]

McCluggage WG, Young RH. Ovarian sertoli-leydig cell tumors with pseudoendometrioid tubules (pseudoendometrioid sertoli-leydig cell tumors). Am J Surg Pathol. 2007 31 592-597. [Pg.759]

Roth LM, Liban E, Czernobilsky B. Ovarian endometrioid tumors mimicking Sertoli and Sertoli-Leydig cell tumors Sertoli-form variant of endometrioid carcinoma. Cancer. 1982 50 1322-1331. [Pg.759]

Sex cord stromal tumors derive from coelomic epithelium or mesenchymal cells of the embryonic gonads [54], Eight percent of all ovarian neoplasms account for this tumor type, with granulosa cell tumors, fibrothecomas, and Sertoli-Leydig cell tumors comprising the majority of these tumors. In contrast... [Pg.256]

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