Serotonin receptors pharmacological aspects

Ibogaine can affect several aspects of serotonergic transmission at concentrations that are readily achieved in the brain following pharmacologically relevant doses [reviewed by Sershen et al. (I8S)]. Because multiple serotonin receptor subtypes, as well as serotonin re-uptake, are modulated by ibogaine, it is not surprising that the effects of this alkaloid on steady-... 

It has been reported that serotonin can produce opposite and complementary action on neuronal functioning, maturation, proliferation and apoptosis, depending on the kind and the density of receptors synthesized by the cells [1]. There are at least fourteen different receptor subtypes described for 5-HT, 13 different heptahelical G-protein-coupled receptors and one ligand-gated ion channel (Table 3). The 5-HT receptor family has been, and is at present, subjected to intense research. Excellent and complete reviews of functional, molecular and pharmacological aspects of 5-HT receptors have been published [5-7]. 

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