Serotonin interactions

Ferris, C. F., and Delville, Y. 1994. Vasopressin and serotonin interactions in the control of agonistic behavior. Psychoneuroendocrinology 19 593-602. 

The mammalian brain appears to have an abundance of sites with which serotonin interacts. Fourteen... 

The function of serotonin in enterochromaffin cells is not fully understood. These cells synthesize serotonin, store the amine in a complex with ATP and with other substances in granules, and release serotonin in response to mechanical and neuronal stimuli. This paracrine serotonin interacts with several 5-HT receptors in the gut. Some of the released serotonin diffuses into blood vessels and is taken up and stored in platelets. 

Porter RJ, Gallagher P, Watson S, Young AH. Corticosteroid-serotonin interactions in depression a review of the human evidence. Psychopharmacology (Berl). 2004 173 1-17. 

Myint Am, Kim YK. Cytokine-serotonin interaction through IDO A neurodegeneration of depression. Med Hypotheses 2003 61 519-525. 

Ruggiero DA, Underwood MD, Rice PM, Mann JJ, Arango V (1999) Corticotropic-releasing hormone and serotonin interact in the human brainstem behavioural implications. Neuroscience 91 1343-1354... 

Ferre S, Artigas F (1995) Clozapine decreases serotonin extracellular levels in the nucleus accum-bens by a dopamine receptor-independent mechanism. Neurosci Lett 187 61 -4 Ferris CF, Melloni RH Jr, Koppel G, Perry KW, Fuller RW, Delville Y (1997) Vasopressin/ serotonin interactions in the anterior hypothalamus control aggressive behavior in golden hamsters. J Neurosci 17 4331 40... 

It is believed that SSRIs produce movement disorders by facilitating inhibitory serotonin interactions with dopamine pathways. While all SSRIs are potent inhibitors of serotonin re-uptake, they have other pharmacological actions that might contribute to their clinical profile. Sertraline has an appreciable affinity for the dopamine re-uptake site, and for this reason might be presumed less likely to cause movement disorders than other SSRIs. However, there is little clinical evidence to support this suggestion and a case of sertraline-induced parkinsonism has been reported (13). 

Di Pietro NC, Seamans JK. Dopamine and serotonin interactions in the prefrontal cortex insights on antipsychotic drugs and their mechanism of action. Pharmacopsychiatry 2007 40(Suppl l) S27-33. 

Rubinow DR, Schmidt PJ, Roca CA. Estrogen-serotonin interactions Implications for affective regulation. Biol Psychiatry 1998 44 839-850. 

Serotonin interacts with type 2 (5-HT2) serotonin receptors on smooth muscle cells underlying vascular endothelial cells to cause vasoconstriction. In normal tissues this effect is balanced with its capacity to cause vascular endothelial cells to release nitric oxide, a vascular relaxing factor (29). Serotonin appears to induce selective vasoconstriction of the arterioles supplying tumors, leading to a selective decrease in tumor blood flow (24). Serotonin has the potential to be used clinically, particularly because unwanted side effects may be reduced with specific antagonists of other types of serotonin receptors. Alternatively, specific agonists of 5-HT2 receptors may be useful in this approach. 

Ersche KD, Cumming P, Craig KJ, Muller U, Fineberg NA, BuUmore ET, et al. Amisulpride-induced acute akathisia in OCD an example of dysfunctional dopamine-serotonin interactions J Psychopharmacol 2012 26(6) 887-90. 

S100A10 was found to interact with the serotonin IB receptor increasing its presence at the cell membrane. S100A10 was found to be closely associated with the pathophysiology of depression. 

A final, important distinction between sibutramine and (7-fenfluramine is that the actions of the former, but not the latter, rest on its modification of both 5-HT and noradrenergic transmission. Thus, the reduction in food intake by sibutramine is partially blocked by ai- or jSi-adrenoceptor antagonists as well as 5-HT2a/2C or 5-HT2b/2c antagonists. In fact, there appears to be a synergistic interaction between these two transmitter systems. This is illustrated by a study of the effects of the selective serotonin... 

RESPONSE Yes, and there is some recent study too that was done by Lyness showing that if the serotonin system is destroyed, toxicity and seh-admirhstration of amphetamines are increased. There is a lot of evidence that some of this interaction does occur at some level, but we don t know where yet. 

H]MDMA interacted with multiple sites in rat brain. A low affinity pH]MDA binding site (apparent Kd>1.0 mM) was found to be resistant to boiling of the synaptosomal preparation for 15 minutes. This site was saturable, as indicated by a 30 pereent inhibition of [ H]MDA binding to boiled synaptosomes by 1.0 mM MDA and a 56 pereent inhibition of the binding by 0.1 mM of the serotonin uptake bloeker paroxetine. The indication of a saturable, nonspecific binding site for [ H]MDA in boiled membranes necessitated that we use boiled tissue to assess nonspecific binding in all subsequent experiments. 

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