Serendipity, drug design

The lead discovery process is depicted in Figure 10.4-4 and shows how the different methods are interconnected. A lead structure can be discovered by serendipity. In rational drug design all information available about a target serves to direct... 

Salemme FR, Spurlino J, Bone R. Serendipity meets precision the integration of structure-based drug design and combinatorial chemistry for efficient drug discovery. Structure 1997 5 319-324. 

Kubinyi, H. (1999) Chance favors the prepared mind—from serendipity to rational drug design../. Recep. Signal Transduc. Research 19, 15-39. 

Although serendipity has been quite successful in drug design, it is a method that is difficult to reproduce. Accordingly, over the past fifty years, a variety of other drug discovery methods have been pioneered. 

Given the importance of immunomodulators, this is a drug design area that is too important to be left to the vagaries of serendipity. The cytokines represent the best hope for rational drug design in the area of immunomodulation. 

Key Words Serotonin agonists serotonin antagonists selectivity drug design standard series deconstruction-reconstruction-elaboration serendipity. 

Many drugs such as the sulphonamides introduced by Domagk or penicillin by Fleming were discovered by serendipity and not as a result of rational drug design. ... 

F. R. Salemme, J. Spurlino, and R. Bone, Structure, S, 319 (1997). Serendipity Meets Precision The Integration of Structure-Based Drug Design and Combinatorial Chemistry for Efficient Drug Discovery. 

Most researchers and drug companies, however, still appear to he conhdent that combinatorial chemistry holds untold promise for the future. Though they often admit that there is little to show hy way of approved products that have evolved from combinatorial techniques, they point out that the early years of new technologies are often marked by similar stories of limited success. Eventually, they say, comhinatorial chemistry will take its place with natural products, trial and error, serendipity, and other traditional roads to drug development as an essential tool in the design and production of new pharmaceutical products. 

DESIGNING DRUG MOLECULES TO FIT RECEPTORS 3.2.2 Lead Compound Identification by Serendipity... 

---