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Lead compounds identification

The first step in designing a new compound is to find compounds that have even a slight amount of usefulness for the intended purpose. These are called lead compounds. Once such compounds are identified, the problem becomes one of refinement. Computational techniques are a fairly minor part of finding lead compounds. The use of computer-based techniques for lead compound identification is usually limited to searching databases for compounds similar to known lead compounds or known to treat diseases with similar causes or symptoms. [Pg.296]

Lead Compound Identification— A Short History of Drug Discovery... [Pg.108]

DESIGNING DRUG MOLECULES TO FIT RECEPTORS 3.2.2 Lead Compound Identification by Serendipity... [Pg.111]

Lead Compound Identification from Endogenous Sources... [Pg.112]

Lead Compound Identification from Exogenous Sources Ethnopharmacology... [Pg.115]

Lead Compound Identification by Rational Drug Design... [Pg.117]

Lead Compound Identification by Combinatorial Chemistry with High Throughput Screening... [Pg.121]

The evolution of methods for combinatorial syntheses and high throughput screening will be necessary to address the explosion of druggable targets soon to be identified by the genomics and proteomics revolutions. Genomics and proteomics represent the future of lead compound identification. [Pg.125]

Lead Compound Identification through Genomics and Proteomics... [Pg.125]


See other pages where Lead compounds identification is mentioned: [Pg.31]    [Pg.276]    [Pg.115]    [Pg.185]    [Pg.66]    [Pg.398]    [Pg.142]    [Pg.42]    [Pg.320]    [Pg.128]    [Pg.427]   


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