Sequential Method for Rapid Screening

The micro-mixer is supplied continuously with two carrier fluids, either two immiscible liquids or a gas and a liquid. During screening, pulses of the dissolved catalyst to be screened and the substrate are injected simultaneously by a pipetting robot. The pulses are then mixed in a micro-mixer and form short defined reacting segments that move along the tubular reactor. 

As a reaction in a gas-liquid multiphase system, the enantioselective hydrogenation of (Z)-(a)-acetamidocinnamic methyl ester has been investigated [50]. 

The micro-mixer then generates a continuous foam flow composed of small bubbles of hydrogen (ca. 200 pm in diameter) in the liquid (ethylene glycol-water 

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