Sequence , insight into thermodynamic

The tolerance of the protein folding process to noise in the interaction parameters and sequence modifications [93] was also studied using a 3x3x4 target structure [94]. The conclusions were in agreement with the qualitative picture of real protein folding dynamics and thermodynamics [93]. Such studies are important because they may provide some insights into how specific the protein sequence has to be in order to maintain the structural uniqueness of the native conformation. 

The progress of adiabatic biocalorimetry in the last ten years has enabled us to gain insight into a new field of nucleic acid-conformation-transitions. Besides the canonical B-DNA helix to coil transitions of the linear DNA sequences we have evaluated the conformational changes of a series of new secondary structures and gained access to a complete thermodynamic data set for all linear sequences as function of two fundamental system parameters, namely the net GC content of the given sequence and the counter ion concentration. 

Accurate prediction of the most plausible secondary structure of an RNA molecule based on its sequence can provide valuable insights into the tertiary structure and function of the RNA. Thermodynamically, an optimal structure is the structure with the minimum free energy. How can we find such a structure ... 

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