Separation of Bi-Naphthol Enantiomers

The separation of bi-naphthol enantiomers can be performed using a Pirkle-type stationary phase, the 3,5-dinitrobenzoyl phenylglycine covalently bonded to silica gel. Eight columns (105 mm length) were packed with particle diameter of 25 0 fiva. The solvent is a 72 28 (v/v) heptane isopropanol mixture. The feed concentration is 2.9 g for each enantiomer. The adsorption equilibrium isotherms were determined by the Separex group and already reported in Equation (28) [33]. 

Pirkle CSPs have been used for LC separations of the enantiomers of alcohols, sulfoxides, bi-(3-naphthols, (3-hydroxysulfides, heterocycles such as hydantoins, succinimides, and agents related to propranolol. These phases have also been used in SFC for the separation of phosphine oxide enantiomers.40... 

Pais L. S., Loureiro J. M., Rodrigues A. E. (1997b) Modeling, Simulation and Operation of a Simulated Moving Bed for Continuous Chromatographie Separation of l,l -bi-2-naphthol Enantiomers, J. Chromatogr. A 169 25-35. 

Pais, L., Loureiro, J., Rodrigues, A. Separation of l,l-bi-2-naphthol enantiomers by continuous chromatography in simulated moving bed, Chem. Eng. Sci., 1997a, 52, 245-257. 

Pais, L., Lourerro, J., and Rodrigues, A. (1997b) Modeling, simulation and operation of a simulated moving bed for continuous chromatographic separation of l,l-bi-2-naphthol enantiomers./. Chromatogr. A, 769, 25—35. 

In another study of Pais et al. [18, 19] the enantiomer separation of 1, I -bi-naphthol was investigated in a commercial SMB plant (Licosep 12-26, Separex, France). For the separation, 8 columns of an inner diameter of 26mm were used. 

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