Semisolid powder filling

Capsules are dosage forms in which unit doses of powder, semisolid, or liquid drugs are enclosed within a hard or a soft envelope, or shell. Examples of currently compounded capsules are given in Table 1 with the contents as powders, in oil, or in a semisolid-filled capsule, and modified strength capsules. 

Tablets are broken by chewing before swallowing with water Disintegrate in oral cavity without drinking water to form a suspension for ease of swallowing Two-piece capsule shells filled with granules, powders, pellets, minitablets, sprinkles, semisolids, oils One-piece capsules filled with oily liquid Single-dose unit bag containing granules...

Automatic-filling machines are available, which can have more than one product-dosing device. Therefore, combinations of materials can be filled into the same capsule, such as mixture of a powder and a semisolid formulation or a powder and a tablet. The same formulation rules apply as to single forms. Combinations of materials allow the formulator to achieve specific goals in terms of product stability and types of release. 

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