Semisolid drugs

Semireinforcing blacks, 21 776 Semirigid foams, 25 470 Semirigid food packaging, 18 47-51 Semisolid drug dosage forms, 18 713 Semisolid resins, 10 372 Semisweet chocolate, 6 362 Semisynthetic 14-membered macrolides, 15 280-287... 

For liquid or semisolid drug products such as parenterals, emulsions, suspensions, dermal creams, etc., the issue of "direct exposure" is not clearly addressed and can be somewhat confusing. The ICH guideline states, "Where practicable when testing samples of the drug product outside the primary pack, these should be presented in a way similar to the conditions mentioned for the drug substance."... 

Because semisolid drugs require a different handling than solid drugs, it is important to consider the experimental conditions for in vitro photostability testing. Due to the limited penetration depth of the incident radiation, it is important to provide samples of constant thickness. As noted previously, the "volume effect" can affect the result obtained. Furthermore, the sample area must also be kept constant if repeatable results are to be obtained. 

Effect of Moisture and Humidity on Solid and Semisolid Drugs... 

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