Semduramicin in chicken

LC-ISP-MS proved to be an attractive approach for the determination of semduramicin in chicken liver (120). Tandem MS using CID of the molecular ions could further enhance the specificity, providing structure elucidation and selective detection down to 30 ppb under SRM conditions. 

Liquid chromatography-ionspray-mass spectrometry has been shown to be an attractive approach for the determination of semduramicin in chicken liver. Tandem MS using the CID of the molecular ions further enhanced the specificity providing strucmre elucidation and selective detection down to 30 ppb. Liquid chromatography-ionspray-mass spectrometry has also been successfully applied for the assay of 21 sulfonamides in salmon flesh. Coupling of LC with either ISP-MS or ISP-MS-MS has also been investigated as an attractive alternative for the determination of erythromycin A and its metabolites in salmon tissue. The combination of these methods permitted the identification of a number of degradation products and metabolites of erythromycin at the 10-50 ppb level. Tandem MS with CID has also been... 

Liquid chromatography-ionspray-mass spectrometry has been shown to be an attractive approach for the determination of semduramicin in chicken liver. 

Radiotracer Studies in Poultry. The radiotracer study characterized the depletion of total residues in edible tissues of 37-day old broiler chickens that received 7-day s ad libitum access to feed medicated with 25 ppm l4C-semduramicin sodium. Residues in edible tissues were determined at 6,12,24,48 and 120 hours after treatment. The tissue containing the highest total residues at all withdrawal times was liver. Liver residues were 1.8 or more times higher than residues in the next highest tissues, fat or skin. Total residues in liver were depleted from a mean value of 0.273 pg/g at 6 hours to 0.058 pg/g at 24 hours, and eventually to 0.018 pg/g at 120 hours (Table II). 

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