Self-mediated networks

The conversion from apohost to clathrate structure requires that the diol molecules can reversibly switch from a situation in which the host molecules interact with themselves (self-mediated network) to another in which they interact with the guests (guest-mediated network), with a concomitant rearrangement of geometric parameters d and A. 

As described earlier under "Analysis of apohost structures, the assembly of waad molecules is based on OH... X (X=N, anion, tt) or hydrogen bonds between host molecules, or can be mediated by the guest (G) via OH... G interactions. In the former case we define the strucmre as a self-mediated network, in the latter as a guest-mediated network (Scheme 4.4). 

Schultze, U., Orlikowski, W. J. (2004). A practice perspective on technology-mediated network relations The use of Internet-based self-serve technologies. Information Systems Research, 15(1), 87-106. 

In erythrocytes and most other cells, the major structural link of plasma membranes to the cytoskeleton is mediated by interactions between ankyrin and various integral membrane proteins, including Cf/HCOj antiporters, sodium ion pumps and voltage-dependent sodium ion channels. Ankyrin also binds to the =100 nm, rod-shaped, antiparallel a(3 heterodimers of spectrin and thus secures the cytoskeleton to the plasma membrane. Spectrin dimers self-associate to form tetramers and further to form a polygonal network parallel to the plasma membrane (Fig. 2-9D). Neurons contain both spectrin I, also termed erythroid spectrin, and spectrin II, also termed fodrin. Spectrin II is found throughout neurons, including axons, and binds to microtubules, whereas spectrin I occurs only in the soma and dendrites. 

In the first case, the details of network build-up and modification of network structure described above are not very important. The main aim of crosslinking is to keep the dendritic structures together permanently. Formation of three-dimensional nanostructures by metal-mediated self-assemblage can serve as an example Exo-tridentate tripyridyl compounds self-assemble upon treatment with (en)Pd(N03)2 [66]. 

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