Self-immolative dendritic prodrugs

FIGURE 5.14 Chemical structures of AB3 self-immolative dendritic prodrugs with melpha-lan tail units and a trigger that is activated by PGA. (See the color version of this figure in Color Plates section.)... 

Shamis, M. Lode, H. N. Shabat, D. Bioactivation of self-immolative dendritic prodrugs by catalytic antibody 38C2. J. Am. Chem. Soc. 2004, 126, 1726-1731. 

FIGURE 5.33 Molecular structure of second-generation, self-immolative, dendritic CPT prodrug with a trigger designed for activation by PGA. 

Gopin, A. Ebner, S. Attali, B. Shabat, D. Enzymatic activation of second-generation dendritic prodrugs conjugation of self-immolative dendrimers with poly(ethylene glycol) via click chemistry. Bioconj. Chem. 2006, 17, 1432-1440. 

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